ABSTRACT
Objective To compare the effects of different doses of atorvastatin on lipid lowering in patients with hyperlipidemia and type 2 diabetes mellitus.Methods From January 2014 to December 2016,140 patient with hyperlipidemia and type 2 diabetes mellitus in our hospital for diagnosis and treatment were selected as the research object,all the patients were divided into observation group and control group with 70 cases in each group accorded to randomly.The control group was given low-dose atorvastatin treatment,the observation group was given high-dose atorvastatin treatment,all patients were observed for 4 week.Results The blood glucose and glycated hemoglobin in the observation group and the control group after treatment were significantly lower than that before treatment (P ＜ 0.05),and compared between the two groups were not significant difference compared.The TG,TC and LDL-C in the observation group and the control group after treatment were lower than before treatment,HDL-C was higher than that before treatment (P ＜ 0.05),and the TG,TC,HDL-C and LDL-C in the observation group after treatment were significantly difference compared with the control group (P ＜ 0.05).After treatment,the total efficiency in observation group and the control group were 95.7％ and 97.1％,there was no significant difference compared between the two groups.After treatment followed-up 6 months,the arrhythmia,heart failure,cardiogenic shock and complication rate in the observation group was 8.6％,so that was 27.1％ in the control group,the observation group was significantly less than the control group (P ＜ 0.05).Conclusion Atorvastatin in treatment of hyperlipidemia patients with type 2 diabetes has good effect,especially high-dose atorvastatin has better lipid lowering effect,thereby reduce the follow-up cardiovascular complications,and has very good application value.
ABSTRACT
Objective To develop a cellular shear stress loading system with an adjustable stress mode and relevant parameters, and subsequently verify the effectiveness and feasibility of this system. Methods The hardware of the system was developed by using a peristaltic pump and self-designed multi-channel flow chamber, and the mode control program of shear stress based on LabVIEW was designed to control the device via RS485 interfacing and Modbus protocol. Additionally, the relationship between the shear stress and system parameters was calibrated, and finite element analysis was also conducted. Finally, the feasibility of the system was confirmed via the in vitro cell experiment. Results The mode and magnitude of shear stress of the system could be controlled via either the peristaltic pump or computer, and the cellular long-term effect was also able to be detected. The calibration results of the system indicated that the level of shear stress exhibited significantly linear positive correlation with the revolution of the peristaltic pump (P<0.001). Finite element analysis demonstrated that the level of shear stress on the slide was uniformly distributed and the result of simulation was accordant with calibration. Cytoskeleton staining suggested that cellular morphology of MLO-Y4 cells was changed, and microfilament increased and arrayed along fluid flow direction. Conclusion The system is stable and reliable enough to provide different loading modes and magnitude of cellular shear stress to offer a convictive platform of the research for different cellular stress signal transduction mecha-nisms.
ABSTRACT
Objective To compare the effects of different doses of atorvastatin on lipid lowering in patients with hyperlipidemia and type 2 diabetes mellitus.Methods From January 2014 to December 2016,140 patient with hyperlipidemia and type 2 diabetes mellitus in our hospital for diagnosis and treatment were selected as the research object,all the patients were divided into observation group and control group with 70 cases in each group accorded to randomly.The control group was given low-dose atorvastatin treatment,the observation group was given high-dose atorvastatin treatment,all patients were observed for 4 week.Results The blood glucose and glycated hemoglobin in the observation group and the control group after treatment were significantly lower than that before treatment (P ＜ 0.05),and compared between the two groups were not significant difference compared.The TG,TC and LDL-C in the observation group and the control group after treatment were lower than before treatment,HDL-C was higher than that before treatment (P ＜ 0.05),and the TG,TC,HDL-C and LDL-C in the observation group after treatment were significantly difference compared with the control group (P ＜ 0.05).After treatment,the total efficiency in observation group and the control group were 95.7％ and 97.1％,there was no significant difference compared between the two groups.After treatment followed-up 6 months,the arrhythmia,heart failure,cardiogenic shock and complication rate in the observation group was 8.6％,so that was 27.1％ in the control group,the observation group was significantly less than the control group (P ＜ 0.05).Conclusion Atorvastatin in treatment of hyperlipidemia patients with type 2 diabetes has good effect,especially high-dose atorvastatin has better lipid lowering effect,thereby reduce the follow-up cardiovascular complications,and has very good application value.